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Screening Assay for Enzymes Involved in Pathophysiology Using SELDI-TOF Mass Spectrometr
Pharmacology and Toxicology Faculty Publications
Document Type
Patent
Publication Date
2-19-2008
Disciplines
Abstract
The invention provides methods for quantifying enzymatic activity of an enzyme with a known substrate. The methods employ SELDI-TOF mass spectrometry, and are suitable, in particular, for assaying aspects of the renin-angiotensin system. The methods may be utilized to assess and/or monitor biological conditions associated with the renin-angiotensin system prior to the manifestation of known physiological and biomarkers for such conditions. The methods are suitable for analysis of pharmacological effectors of the renin-angiotensin system, and are particularly suitable for automation and high-throughput screening assay design.
Citation Information
Khalid M. Elased and Mariana Morris. "Screening Assay for Enzymes Involved in Pathophysiology Using SELDI-TOF Mass Spectrometr" (2008) Available at: http://works.bepress.com/khalid_elased/47/
United States Patent Application 20060160167