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Electrostatic Interactions Affect Nanoparticle-Mediated Toxicity to Gram-Negative Bacterium Pseudomonas aeruginosa PAO1
Langmuir
  • Kevin Feris, Boise State University
  • Caitlin Otto, Boise State University
  • Juliette Tinker, Boise State University
  • Denise G. Wingett, Boise State University
  • Alex Punnoose, Boise State University
  • Aaron Thurber, Boise State University
  • Madhu Kongara, Boise State University
  • Maryam Sabetian, Boise State University
  • Bonnie Quinn, St. Francis Xavier University
  • Charles Hanna, Boise State University
  • David Pink, St. Francis Xavier University
Document Type
Article
Publication Date
3-16-2010
Disciplines
Abstract
Nanoscale materials can have cytotoxic effects. Here we present the first combined empirical and theoretical investigation of the influence of electrostatic attraction on nanoparticle cytotoxicity. Modeling electrostatic interactions between cells and 13 nm spheres of zinc oxide nanoparticles provided insight into empirically determined variations of the minimum inhibitory concentrations between four differently charged isogenic strains of Pseudomonas aeruginosa PAO1. We conclude that controlling the electrostatic attraction between nanoparticles and their cellular targets may permit the modulation of nanoparticle cytotoxicity.
Citation Information
Kevin Feris, Caitlin Otto, Juliette Tinker, Denise G. Wingett, et al.. "Electrostatic Interactions Affect Nanoparticle-Mediated Toxicity to Gram-Negative Bacterium Pseudomonas aeruginosa PAO1" Langmuir (2010)
Available at: http://works.bepress.com/kevin_feris/9/