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Article
Natural killer cells in patients with severe chronic fatigue syndrome
Autoimmunity Highlights
  • Ekua Brenu, Griffith University
  • Sharni Hardcastle, Griffith University
  • Gunn Atkinson, Griffith University
  • Mieke Van Driel, Queensland Health
  • Sanne Kreijkamp-Kaspers, Bond University
  • Kevin Ashton, Bond University
  • Don Staines, Griffith University
  • Sonja Marshall-Gradisnik, Griffith University
Date of this Version
1-1-2013
Document Type
Journal Article
Publication Details

Citation only

Brenu, E.W., Hardcastle, S.L., Atkinson, G.M., van Driel, M.L., Kreijkamp-Kaspers, S., Ashton K.J., Staines, D.R., & Marshall-Gradisnik, SM. (2013). Natural killer cells in patients with severe chronic fatigue syndrome. Autoimmunity Highlights, 4(3), 69-80.

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2013 HERDC submission. FoR code: 110300; 170100

© Copyright, Springer, 2013

Abstract

Maintenance of health and physiological homeostasis is a synergistic process involving tight regulation of proteins, transcription factors and other molecular processes. The immune system consists of innate and adaptive immune cells that are required to sustain immunity. The presence of pathogens and tumour cells activates innate immune cells, in particular Natural Killer (NK) cells. Stochastic expression of NK receptors activates either inhibitory or activating signals and results in cytokine production and activation of pathways that result in apoptosis of target cells. Thus, NK cells are a necessary component of the immunological process and aberrations in their functional processes, including equivocal levels of NK cells and cytotoxic activity pre-empts recurrent viral infections, autoimmune diseases and altered inflammatory responses. NK cells are implicated in a number of diseases including chronic fatigue syndrome (CFS). The purpose of this review is to highlight the different profiles of NK cells reported in CFS patients and to determine the extent of NK immune dysfunction in subtypes of CFS patients based on severity in symptoms.

Citation Information
Ekua Brenu, Sharni Hardcastle, Gunn Atkinson, Mieke Van Driel, et al.. "Natural killer cells in patients with severe chronic fatigue syndrome" Autoimmunity Highlights (2013) ISSN: 2038-0305
Available at: http://works.bepress.com/kevin_ashton/17/