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Human cerebral circuitry related to cardiac control: A neuroimaging meta-analysis
Annals of Neurology
  • Estefanía Ruiz Vargas, Western University, Ivey Business School
  • Peter Sörös, Universität zu Lübeck
  • J. Kevin Shoemaker, Western University
  • Vladimir Hachinski, Western University
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© 2016 American Neurological Association. Serious arrhythmias often follow stroke, highlighting the important role that the cerebral cortex has in neural regulation of the heart. Neuroimaging studies reveal patterns of activation associated with autonomic cardiovascular responses. Using the activation likelihood estimation, a meta-analysis was performed to identify cortical activation patterns related to heart rate and heart rate variability across studies that used differing stimuli of cardiovascular arousal. Consistent associations with heart rate and heart rate variability were observed in the anterior cingulate, amygdala, insula, and prefrontal cortex, among others. Also, evidence is provided of insular lateralization associated with autonomic cardiac responses. Ann Neurol 2016;79:709-716

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Estefanía Ruiz Vargas, Peter Sörös, J. Kevin Shoemaker and Vladimir Hachinski. "Human cerebral circuitry related to cardiac control: A neuroimaging meta-analysis" Annals of Neurology Vol. 79 Iss. 5 (2016) p. 709 - 716
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