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Study of the Chemical and Physical Influences upon in Vitro Peptide-Mediated Silica Formation
  • Francisco Rodríguez, University of Dayton
  • Diana D. Glawe, Trinity University
  • Rajesh R. Naik, Air Force Research Laboratory
  • Kevin P. Hallinan, University of Dayton
  • Morley O. Stone, Air Force Research Laboratory
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Herein, we report on the ability to create complex 2-D and 3-D silica networks in vitro via polycationic peptide-mediated biosilicification under experimentally altered chemical and physical influences. These structures differ from the sphere-like silica network of particles obtained in vitro under static conditions. Under chemical influences, overall morphologies were observed to shift from a characteristic network of sphere-like silica particles to a sheetlike structure in the presence of −OH groups from additives and to sharp-edged, platelike structures in the presence of larger polycationic peptide matrixes. Under physical influences, using externally applied force fields, overall silica morphologies were observed to transition from sphere-like to fiberlike and dendrite-like structures. These findings could lead to the future development of bio-inspired complex 2-D and 3-D silica micro- and nano-devices.
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American Chemical Society
Peer Reviewed
Citation Information
Francisco Rodríguez, Diana D. Glawe, Rajesh R. Naik, Kevin P. Hallinan, et al.. "Study of the Chemical and Physical Influences upon in Vitro Peptide-Mediated Silica Formation" Biomacromolecules Vol. 5 Iss. 2 (2004)
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