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Structural Insights into the Architecture of the Hyperthermophilic Fusellovirus SSV1
  • Kenneth M. Stedman, Portland State University
  • Melissa DeYoung, Portland State University
  • Mitul Saha, University of Texas Medical Branch
  • Michael B. Sherman, University of Texas Medical Branch
  • Marc C. Morais, University of Texas Medical Branch
Document Type
Publication Date
  • Virology research,
  • Archaebacteria -- Host-virus relationships,
  • Thermophilic microorganisms,
  • Biology,
  • Genomics,
  • Microbiology
The structure and assembly of many icosahedral and helical viruses are well-characterized. However, the molecular basis for the unique spindle-shaped morphology of many viruses that infect Archaea remains unknown. To understand the architecture and assembly of these viruses, the spindle-shaped virus SSV1 was examined using cryo-EM, providing the first 3D-structure of a spindle-shaped virus as well as insight into SSV1 biology, assembly and evolution. Furthermore, a geometric framework underlying the distinct spindle-shaped structure is proposed.

Copyright 2014 Published by Elsevier Inc.

The version of record will be available one year from date of publication and can be found now at the publisher's website.

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Citation Information
Kenneth M. Stedman, Melissa DeYoung, Mitul Saha, Michael B. Sherman, Marc C. Morais, Structural insights into the architecture of the hyperthermophilic Fusellovirus SSV1, Virology, Volume 474, 1 January 2015, Pages 105-109, ISSN 0042-6822,