Structural Insights into the Architecture of the Hyperthermophilic Fusellovirus SSV1Virology
SponsorThis work was supported by Portland State University and National Science Foundation Research Grant 1243963 (to K.M.S. and M.C.M.) and Grant 0702020 to K.M.S.
- Virology research,
- Archaebacteria -- Host-virus relationships,
- Thermophilic microorganisms,
AbstractThe structure and assembly of many icosahedral and helical viruses are well-characterized. However, the molecular basis for the unique spindle-shaped morphology of many viruses that infect Archaea remains unknown. To understand the architecture and assembly of these viruses, the spindle-shaped virus SSV1 was examined using cryo-EM, providing the ﬁrst 3D-structure of a spindle-shaped virus as well as insight into SSV1 biology, assembly and evolution. Furthermore, a geometric framework underlying the distinct spindle-shaped structure is proposed.
Citation InformationKenneth M. Stedman, Melissa DeYoung, Mitul Saha, Michael B. Sherman, Marc C. Morais, Structural insights into the architecture of the hyperthermophilic Fusellovirus SSV1, Virology, Volume 474, 1 January 2015, Pages 105-109, ISSN 0042-6822, http://dx.doi.org/10.1016/j.virol.2014.10.014.