The objective of this study was to compare live and digital methodologies to measure nursery pig approachability pre- and post-vaccination. A total of 149 pens housing approximately 19 barrows and gilts/pen (a mix of approximately 50% barrows and 50% gilts; 0.3 m2/pig) were used. Pigs were approximately 6 weeks of age. The pen applied injection treatments were (1) Ingelvac CircoFLEX®/Ingelvac MycoFLEX® vaccine, (2) Circumvent® PCVM vaccine (3) Saline. Pre-injection were conducted at 1600h the day before injections were administered. Pigs received their treatments at 1000h on the consecutive day and post-injection was conducted, 6 h after treatments were administered and 24 h after pre-injection observations. An animal-human interaction tests was completed at pre- and post-injection time points using a live- and digital image methodology. The experimental unit was the pen of pigs. The statistical model evaluating methodologies used PROC GLIMMIX. A P ≤ 0.05 value was considered to be significant. There were no pre- or post-injection approach and not differences comparing the live and digital image evaluation methodologies. In conclusion, the live observation information is very useful when considering a real-time human-animal based measure during an on-farm assessment.