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Article
Weight gain in pregnancy and risk of maternal hyperglycemia
American Journal of Obstetrics and Gynecology
  • Sharon J. Herring
  • Emily Oken
  • Sheryl L. Rifas-Shiman
  • Janet W. Rich-Edwards
  • Alison M. Stuebe
  • Ken P. Kleinman
  • Matthew W. Gillman
Publication Date
2009
Abstract
OBJECTIVE: The purpose of this study was to examine associations of weight gain from prepregnancy to glycemic screening with glucose tolerance status. STUDY DESIGN: Main outcomes were failed glycemic screening (1-hour glucose result >or= 140 mg/dL) with either 1 high value on 3-hour oral glucose tolerance testing (impaired glucose tolerance in pregnancy) or >or= 2 high values on 3-hour oral glucose tolerance testing (gestational diabetes mellitus). We performed multinomial logistic regression to determine the odds of these glucose intolerance outcomes by quartile of gestational weight gain among 1960 women in Project Viva. RESULTS: Mean gestational weight gain was 10.2 +/- 4.3 (SD) kg. Compared with the lowest quartile of weight gain, participants in the highest quartile had an increased odds of impaired glucose tolerance in pregnancy (adjusted odds ratio, 2.54; 95% confidence interval, 1.25-5.15), but not gestational diabetes mellitus (odds ratio, 0.93; 95% confidence interval, 0.50-1.70). CONCLUSION: Higher weight gain predicted impaired glucose tolerance in pregnancy, but not gestational diabetes mellitus.
Disciplines
DOI
10.1016/j.ajog.2009.01.039
Pages
61.e1–61.e7
License
UMass Amherst Open Access Policy
Citation Information
Sharon J. Herring, Emily Oken, Sheryl L. Rifas-Shiman, Janet W. Rich-Edwards, et al.. "Weight gain in pregnancy and risk of maternal hyperglycemia" American Journal of Obstetrics and Gynecology Vol. 201 Iss. 1 (2009)
Available at: http://works.bepress.com/kenneth-kleinman/24/