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Article
Pharmacokinetics of Propofol in Children
British Journal of Anaesthesia (1990)
  • Kelvin Chan
Abstract

The pharmacokinetics of propofol were studied in 12 healthy Chinese children, aged 4-12 yr, undergoing circumcision under inhalation anaesthesia. All patients received a single i.v. bolus dose of propofol 2.5 mg kg-1 and blood concentrations of propofol over the subsequent 24 h were measured using high pressure liquid chromatography with fluorimetric detection. Data were consistent with a three-compartment model with a mean (SEM) elimination half-life of 209 (29) min and total body clearance of 40.4 (3.6) ml min-1 kg-1. The mean (SEM) apparent volume of distribution at steady state was 5.0 (2.7) litre kg-1 and volume of the central compartment was 0.6 (0.1 ) litre kg-1. The mean (SEM) ratio of k12:k21 was 1.4 (0.2), suggesting that, after injection of a single bolus dose in children, propofol is distributed rapidly to the shallow compartment. The mean ratio of k31:k10 suggests that lipophilicity constrains return of the drug to the central compartment.

Keywords
  • Anaesthetics,
  • intravenous,
  • propofol,
  • paediatric,
  • pharmacokinetics,
  • anaesthesia,
  • children
Publication Date
1990
Citation Information
Kelvin Chan. "Pharmacokinetics of Propofol in Children" British Journal of Anaesthesia Vol. 65 (1990)
Available at: http://works.bepress.com/kelvin_chan/75/