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Article
Pharmacokinetics of Pyrazinamide in CSF and Plasma of Rabbits: Influence of Anaesthesia
Asia Pacific Journal of Pharmacology (1987)
  • Kelvin Chan
Abstract

The influence of anaesthesia on the pharmacokinetics of pyrazinamide (PZA) in cerebrospinal fluid (CSF) and plasma of rabbits was investigated. In a cross-over study, seven New Zealand white rabbits were given oral pyrazinamide (30 mg kg-1) on 2 occasions, with intermittent thiopentone and with continuous pentobarbitone anaesthesia. PZA concentrations in CSF and plasma were determined by high performance liquid chromatography (HPLC). The elimination of PZA after rapid absorption, in both occasions, followed a one compartment kinetics. Plasma elimination t1/2 (1.81 ± 0.52 h and 1.34 ± 0.11 h; p < 0.0025) and apparent volume of distribution (1.804 ± 0.836 and 1.542 ± 0.485 L kg-1; p < 0.10) were larger in the continuously anaesthetised group. The rate and peak of absorption were not different. Ratios of CSF to plasma PZA at 0.5 h (0.96 ± 0.07, 1.01 ± 0.15), 1 h (1.03 ± 0.07, 1.05 ± 0.04), 4 h (0.96 ± 0.13, 0.97 ± 0.16), and 6 h (1.17 ± 0.37, 1.12 ± 0.11), with intermittent and continuous anaesthesia respectively, were similar. Thus, continuous anaesthesia may prolong PZA elimination but does not affect its penetration into CSF from the general circulation in rabbits.

Keywords
  • CSF,
  • Plasma pharmacokinetics,
  • Pyrazinamide,
  • Anaesthesia,
  • Rabbits
Publication Date
1987
Citation Information
Kelvin Chan. "Pharmacokinetics of Pyrazinamide in CSF and Plasma of Rabbits: Influence of Anaesthesia" Asia Pacific Journal of Pharmacology Vol. 2 (1987)
Available at: http://works.bepress.com/kelvin_chan/68/