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Article
The effect of incorporation of indomethacin with polyethylene glycol 6000 in a solid dispersion on its in vivo properties in the rat
Agents and Actions (1984)
  • Kelvin Chan
Abstract

Preparations of indomethacin and indomethacin in combination with PEG 6000 were administered in solid form by the oral route to male rats. No significant differences in anti-oedema activity were observed between the different preparations of indomethacin, but high blood levels of drug were observed following dosing with indomethacin, in a PEG 6000 melt. Rapid dispersion formulations of indomethacin were also found to be gastro-toxic.

Keywords
  • indomethacin,
  • rat,
  • polyethylene glycol 6000
Publication Date
1984
Citation Information
Kelvin Chan. "The effect of incorporation of indomethacin with polyethylene glycol 6000 in a solid dispersion on its in vivo properties in the rat" Agents and Actions Vol. 15 (1984)
Available at: http://works.bepress.com/kelvin_chan/65/