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Article
Effect of Antacids on the Plasma Concentration of Phenoperidine
British Journal of Anaesthesia (1983)
  • Kelvin Chan
Abstract

The effect of antacids on the plasma concentration of phenoperidine was studied in six volunteers. All subjects received the same dose of phenoperidine (15µg kg-1) on different occasions in the presence, and absence of, an antacid preparation. In control studies, secondary peaks in the plasma concentration of phenoperidine were invariably observed; these were entirely eliminated, or modified substantially, by the concurrent administration of antacids. In the latter conditions, plasma concentrations of phenoperidine were greater during the first 20min, and the area under the plasma concentration-time curve between 0 and 20 min was significantly greater than in control studies. In contrast, the plasma clearance of the drug was almost identical in control conditions and during treatment with antacids. After the oral administration of phenoperidine to two subjects, the systematic bioavailability of the drug was 9 .9% and 13.9a% respectively.

Keywords
  • Pharmacokinetics,
  • Antacids,
  • plasma concentration,
  • phenoperidine
Publication Date
1983
Citation Information
Kelvin Chan. "Effect of Antacids on the Plasma Concentration of Phenoperidine" British Journal of Anaesthesia Vol. 55 (1983)
Available at: http://works.bepress.com/kelvin_chan/64/