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Article
Effect of Urine pH on the Elimination of Phenoperidine
British Journal of Clinical Pharmacology (1983)
  • Kelvin Chan
Abstract

The effect of urine pH ont he plasma concentration and elimination of phenoperidine and its main metabolites was studied in six volunteers. The clearance of unchanged phenoperidine in acid urine was significantly greater than in neutral or alkaline urine. By contrast, the elimination of its basic metabolites was enhanced in uncontrolled or alkaline urine. Other pharmacokinetic parameters were not significantly affected.

Keywords
  • Phenoperidine,
  • elimination,
  • urine pH
Publication Date
1983
Citation Information
Kelvin Chan. "Effect of Urine pH on the Elimination of Phenoperidine" British Journal of Clinical Pharmacology Vol. 16 (1983)
Available at: http://works.bepress.com/kelvin_chan/63/