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Article
Plasma Concentration of Pyridostigmine During the Antagonism of Neuromuscular Block
British Journal of Anaesthesia (1982)
  • Kelvin Chan
Abstract

The plasma concentrations of pyridostigmine were measured in eight patients during the antagonism of non-depolarizing neuromuscular blockade. After the injection i.v. of pyridostigmine bromide 14.6 mg/70kg, the concentration of the drug rapidly decreased between 2 and 7 min, and then declined more slowly. After 2 h, significant amounts of pyridostigmine were still present in the plasma of all subjects. In the eight patients studied, the initial half-life was 1.0 ± 0.3min and the terminal half-life was 46.4 ± 6.5min (mean ± SEM). Total body clearance of pyridostigmine was 8.7 ± 1.5ml min-1 kg-1, and the total apparent volume of distribution was 536 ± 80 ml kg -1. Possible explanations for the differences between these results and previous studies are considered.

Keywords
  • Plasma Concentration,
  • Pyridostigmine,
  • Neuromuscular Block
Publication Date
1982
Citation Information
Kelvin Chan. "Plasma Concentration of Pyridostigmine During the Antagonism of Neuromuscular Block" British Journal of Anaesthesia Vol. 55 (1982)
Available at: http://works.bepress.com/kelvin_chan/62/