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Article
Clearance of Neostigmine from the Circulation During the Antagonism of Neuromuscular Block
British Journal of Anaesthesia (1978)
  • Kelvin Chan
Abstract

The plasma concentration of neostigmine was measured in five patients during the antagonism of neuromuscular block. The concentration of the drug decreased rapidly between 2 and 5 min after administration, and then more slowly. Detectable concentrations of neostigmine were present in plasma after 60 min. In the five patients the distribution half-life of neostigmine was less than 1 min; the elimination half-life ranged from 15.4 to 30.1 min.

Keywords
  • neostigmine,
  • antagonism of neuromuscular block,
  • reversal
Publication Date
1978
Citation Information
Kelvin Chan. "Clearance of Neostigmine from the Circulation During the Antagonism of Neuromuscular Block" British Journal of Anaesthesia Vol. 50 (1978)
Available at: http://works.bepress.com/kelvin_chan/57/