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Article
Renal Clearance of Pyridostigmine in Patients with Myasthenia gravis
European Neurology (1977)
  • Kelvin Chan
Abstract

The urinary clearance of pyridostigmine was studied in six patients with myasthenia gravis. In three patients on pyridostigmine, alone, renal clearance ranged from 349 to 481 ml/min, corresponding to a pyridostigmine:creatinine clearance ratio of 2.64 to 3.46. In a patient on bendrofluazide as well as pyridostigmine, a similar clearance ratio was observed. By contrast, the urinary clearance of pyridostigmine and the pyridostigmine:creatinine clearance ratio was reduced in two myasthenic patients concurrently treated with other basic drugs. It is suggested that these results may reflect competition for renal tubular excretion.

Keywords
  • Pyridostigmine,
  • myasthenia gravis,
  • renal clearance
Publication Date
1977
Citation Information
Kelvin Chan. "Renal Clearance of Pyridostigmine in Patients with Myasthenia gravis" European Neurology Vol. 16 (1977)
Available at: http://works.bepress.com/kelvin_chan/111/