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Article
pharmacokinetics of pyrazinamide in plasma and CSF of rabbits following intravenous and oral administration
European Journal of Drug Metabolism and Pharmacokinetics (1988)
  • Kelvin Chan
Abstract

The pharmacokinetics of pyrazinamide (PZA) in cerebrospinal fluid (CSF) and plasma of 10 rabbits were studied after separate intravenous (i.v.) and oral (p.o.) administration, in a cross-over study. Concentrations of PZA in biological fluids were determined by high-performance liquid chromatography (HPLC). After p.o. dose PZA was absorbed rapidly and peak plasma concentration was attained at 0.5 h post administration. After i.v. dose, the plasma PZA concentrations declined rapidly within 10 min and subsequently more slowly following a bi-exponential manner. No difference was observed int he area under plasma concentration-time curves indicating oral absorption was complete and no apparent first-pass metabolism occured. The (mean ± S.D.) elimination t1/2 after i.v. (1.04 ± 0.18 h) was significantly shorter (p = 0.0005) than that after oral (1.95 ± 0.63 h) dose and the apparent volume of distribution was also significantly smaller (P = 0.005) after i.v. (3.211 ± 0.412 l) than after oral (5.936 ± 1.607 l) administration. The elimination t1/2 of PZA in CSF was nearly identical to that in plasma after either i.v. (1.07 ± 0.20 h) or p.o. (1.84 ± 0.56 h) administration. There is no apparent barrier in rabbits for the penetration of PZA into CSF from the general circulation.

Keywords
  • pyrazinamide,
  • pharmacokinetics,
  • CSF,
  • plasma,
  • rabbit
Publication Date
1988
Citation Information
Kelvin Chan. "pharmacokinetics of pyrazinamide in plasma and CSF of rabbits following intravenous and oral administration" European Journal of Drug Metabolism and Pharmacokinetics Vol. 13 Iss. 3 (1988)
Available at: http://works.bepress.com/kelvin_chan/110/