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Article
Randomized, Controlled Pilot Trial of Solifenacin Succinate for Overactive Bladder in Parkinson's Disease
Parkinsonism & Related Disorders
  • Theresa A. Zesiewicz, University of South Florida
  • Marian Evatt, Emory University
  • Camille P. Vaughan, Emory University
  • Israt Jahan, University of South Florida
  • Carlos Singer, University of Miami
  • Raul Ordorica, University of South Florida
  • Jason L. Salemi, Baylor College of Medicine
  • Jessica D. Shaw, University of South Florida
  • Kelly L Sullivan, Georgia Southern University
Document Type
Article
Publication Date
1-1-2015
DOI
10.1016/j.parkreldis.2015.02.025
Disciplines
Abstract
Objective: To evaluate the efficacy of solifenacin succinate in Parkinson's disease (PD) patients suffering from overactive bladder (OAB). Background: Urinary dysfunction is a commonly encountered non-motor feature in PD that significantly impacts patient quality of life. Design/methods: This was a double-blind, randomized, placebo-controlled, 3-site study with an open label extension phase to determine the efficacy of solifenacin succinate in idiopathic PD patients with OAB. Patients were randomized to receive solifenacin succinate 5–10 mg daily or placebo for 12 weeks followed by an 8-week open label extension. The primary outcome measure was the change in the mean number of micturitions per 24 h period. Secondary outcome measures included the change in the mean number of urinary incontinence episodes and the mean number of nocturia episodes. Results: Twenty-three patients were randomized in the study. There was no significant improvement in the primary outcome measure in the double-blind phase, but there was an improvement in the number of micturitions per 24 h period in the solifenacin succinate group compared to placebo at a mean dose of 6 mg/day (p = 0.01). In the open label phase, the mean number of urinary incontinence episodes per 24 h period decreased (p = 0.03), as did the number of nocturia episodes per 24 h period (p = 0.01). Adverse events included constipation and xerostomia, which resolved after treatment was discontinued. Conclusions: In this pilot trial, solifenacin succinate treatment led to an improvement in urinary incontinence, despite persistence in other OAB symptoms.
Citation Information
Theresa A. Zesiewicz, Marian Evatt, Camille P. Vaughan, Israt Jahan, et al.. "Randomized, Controlled Pilot Trial of Solifenacin Succinate for Overactive Bladder in Parkinson's Disease" Parkinsonism & Related Disorders (2015)
Available at: http://works.bepress.com/kelly_sullivan/82/