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Evidence-Based Guideline: Treatment of Tardive Syndromes - Report of the Guideline Development Subcommittee of the American Academy of Neurology
Neurology (2013)
  • Roongroj Bhidayasiri, University of California, Los Angeles
  • Stanley Fahn, Columbia University
  • William J. Weiner, University of Maryland
  • Gary S. Gronseth, University of Kansas
  • Kelly L. Sullivan, Georgia Southern University
  • Theresa A. Zesiewicz, University of South Florida
Abstract
Objective: To make evidence-based recommendations regarding management of tardive syndromes (TDS), including tardive dyskinesias (TDD), by addressing 5 questions: 1) Is withdrawal of dopamine receptor blocking agents (DRBAs) an effective TDS treatment? 2) Does switching from typical to atypical DRBAs reduce TDS symptoms? 3) What is the efficacy of pharmacologic agents in treating TDS? 4) Do patients with TDS benefit from chemodenervation with botulinum toxin? 5) Do patients with TDS benefit from surgical therapy?

Methods: PsycINFO, Ovid MEDLINE, EMBASE, Web of Science, and Cochrane were searched (1966–2011). Articles were classified according to a 4-tiered evidence-rating scheme; recommendations were tied to the evidence.

Results and Recommendations: Clonazepam probably improves TDD and ginkgo biloba probably improves TDS (both Level B); both should be considered as treatment. Risperidone may improve TDS but cannot be recommended as treatment because neuroleptics may cause TDS despite masking symptoms. Amantadine and tetrabenazine might be considered as TDS treatment (Level C). Diltiazem should not be considered as TDD treatment (Level B); galantamine and eicosapentaenoic acid may not be considered as treatment (Level C). Data are insufficient to support or refute use of acetazolamide, bromocriptine, thiamine, baclofen, vitamin E, vitamin B6, selegiline, clozapine, olanzapine, melatonin, nifedipine, fluperlapine, sulpiride, flupenthixol, thiopropazate, haloperidol, levetiracetam, quetiapine, ziprasidone, sertindole, aripiprazole, buspirone, yi-gan san, biperiden discontinuation, botulinum toxin type A, electroconvulsive therapy, α-methyldopa, reserpine, and pallidal deep brain stimulation as TDS treatments (Level U). Data are insufficient to support or refute TDS treatment by withdrawing causative agents or switching from typical to atypical DRBA (Level U).

This article has a correction. Please see: https://doi.org/10.1212/01.wnl.0000436080.72985.b0.
Keywords
  • Tardive syndromes,
  • TDS treatment
Disciplines
Publication Date
July 30, 2013
DOI
10.1212/WNL.0b013e31829d86b6
Citation Information
Roongroj Bhidayasiri, Stanley Fahn, William J. Weiner, Gary S. Gronseth, et al.. "Evidence-Based Guideline: Treatment of Tardive Syndromes - Report of the Guideline Development Subcommittee of the American Academy of Neurology" Neurology Vol. 81 Iss. 5 (2013) p. 463 - 469 ISSN: 1526-632X
Available at: http://works.bepress.com/kelly_sullivan/28/