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Article
Evaluation of Humoral Immune Response in Adaptive Immunity in ALS Patients during Disease Progression
Journal of Neuroimmunology (2009)
  • Islam A. Saleh, University of South Florida
  • Theresa A. Zesiewicz, University of South Florida
  • Yong Xie, University of South Florida
  • Kelly L. Sullivan, Georgia Southern University
  • Amber M Miller, University of South Florida
  • Nicole Kuzmin-Nichols, Saneron CCEL Therapeutics, Inc.
  • Paul R. Sanberg, University of South Florida
  • Svitlana Garbuzova-Davis, University of South Florida
Abstract
In ALS, evidence suggests immune reactions in disease pathogenesis. Although immunological changes point to adaptive immune response, whether humoral or cellular response dominates during disease course is unknown. The study aim was to evaluate humoral immune response in ALS patients during disease progression. Circulating immune complexes (CICs), IgG, and IgM in sera of ALS patients and matching controls were evaluated after each of two visits. Results showed significantly elevated CICs and IgG in ALS patient sera. CICs decreased to control levels at the second visit, yet IgG remained higher than controls. Serum IgM was within normal range. Results suggest a humoral immune response initiating adaptive immunity in ALS, however, cellular immune response needs verification.
Keywords
  • Amyotrophic lateral sclerosis,
  • Humoral immune response,
  • Circulating immune complexes,
  • IgG,
  • IgM
Disciplines
Publication Date
October 30, 2009
DOI
10.1016/j.jneuroim.2009.07.011
Citation Information
Islam A. Saleh, Theresa A. Zesiewicz, Yong Xie, Kelly L. Sullivan, et al.. "Evaluation of Humoral Immune Response in Adaptive Immunity in ALS Patients during Disease Progression" Journal of Neuroimmunology Vol. 215 Iss. 1-2 (2009) p. 96 - 101 ISSN: 0165-5728
Available at: http://works.bepress.com/kelly_sullivan/16/