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Selected Works of Keith St. Lawrence
Article
Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
  • Gemma Bale, UCL
  • Ajay Rajaram, Lawson Health Research Institute
  • Matthew Kewin, Lawson Health Research Institute
  • Laura Morrison, Lawson Health Research Institute
  • Alan Bainbridge, Western University
  • Linshan Liu, Lawson Health Research Institute
  • Udunna Anazodo, Lawson Health Research Institute
  • Mamadou Diop, Lawson Health Research Institute
  • Keith St Lawrence, Lawson Health Research Institute
  • Ilias Tachtsidis, UCL
Document Type
Conference Proceeding
Publication Date
1-1-2019
URL with Digital Object Identifier
10.1117/12.2526729
Abstract

© 2019 SPIE. This is the first multimodal study of cerebral tissue metabolism and perfusion post-hypoxic-ischaemic (HI) brain injury with broadband near-infrared spectroscopy (bNIRS), diffuse correlation spectroscopy (DCS), positron emission tomography (PET) and magnetic resonance spectroscopy (MRS). In 5 piglet models of HI, we measured cerebral tissue saturation (StO2), cerebral blood flow (CBF), cerebral oxygen metabolism (CMRO2), changes in the mitochondrial oxidation state of cytochrome-c-oxidase (oxCCO), cerebral glucose metabolism (CMRglc), and tissue biochemistry (Lac+Thr/tNAA). At baseline, the parameters measured were: 64±6 % StO2, 35±11 ml/100g/min CBF, and 2.0±0.4 μmol/100g/min CMRO2. After HI the parameters measured were: 68±6% StO2, 35±6 ml/100g/min CBF, 1.3±0.1 μmol/100g/min CMRO2, 0.4±0.2 Lac+Thr/tNAA, and 9.5±2.0 CMRglc. This study demonstrates the capacity of a multimodal set up to interrogate the pathophysiology of HIE using a combination of optical methods, MRS, and PET.

Citation Information
Gemma Bale, Ajay Rajaram, Matthew Kewin, Laura Morrison, et al.. "Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury" Progress in Biomedical Optics and Imaging - Proceedings of SPIE (2019)
Available at: http://works.bepress.com/keith-stlawrence/6/