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Article
Evaluation of hyperspectral NIRS for quantitative measurements of tissue oxygen saturation by comparison to time-resolved NIRS
Biomedical Optics Express
  • Matthew Kewin, Lawson Health Research Institute
  • Ajay Rajaram, Lawson Health Research Institute
  • Daniel Milej, Lawson Health Research Institute
  • Androu Abdalmalak, Lawson Health Research Institute
  • Laura Morrison, Lawson Health Research Institute
  • Mamadou Diop, Lawson Health Research Institute
  • Keith St Lawrence, Lawson Health Research Institute
Document Type
Article
Publication Date
9-1-2019
URL with Digital Object Identifier
10.1364/BOE.10.004789
Disciplines
Abstract

© 2019 Optical Society of America. Near-infrared spectroscopy (NIRS) is considered ideal for brain monitoring during preterm infancy because it is non-invasive and provides a continuous measure of tissue oxygen saturation (StO2). Hyperspectral NIRS (HS NIRS) is an inexpensive, quantitative modality that can measure tissue optical properties and oxygen saturation (StO2) by differential spectroscopy. In this study, experiments were conducted using newborn piglets to measure StO2 across a range of oxygenation levels from hyperoxia to hypoxia by HS and time-resolved (TR) NIRS for validation. A strong correlation between StO2 measurements from the two techniques was observed (R2 = 0.98, average slope of 1.02 ± 0.28); however, the HS-NIRS estimates were significantly higher than the corresponding TR-NIRS values. These regression results indicate that HS NIRS could become a clinically feasible method for monitoring StO2 in preterm infants.

Citation Information
Matthew Kewin, Ajay Rajaram, Daniel Milej, Androu Abdalmalak, et al.. "Evaluation of hyperspectral NIRS for quantitative measurements of tissue oxygen saturation by comparison to time-resolved NIRS" Biomedical Optics Express (2019) p. 4789 - 4802
Available at: http://works.bepress.com/keith-stlawrence/5/