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Subtraction-based approach for enhancing the depth sensitivity of time-resolved NIRS
Biomedical Optics Express
  • Daniel Milej, Western University
  • Androu Abdalmalak, Western University
  • Peter McLachlan, Western University
  • Mamadou Diop, Western University
  • Adam Liebert, Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences
  • Keith St. Lawrence, Western University
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© 2016 Optical Society of America. The aim of this study was to evaluate enhancing of the depth sensitivity of timeresolved near-infrared spectroscopy with a subtraction-based approach. Due to the complexity of light propagation in a heterogeneous media, and to prove the validity of the proposed method in a heterogeneous turbid media we conducted a broad analysis taking into account a number of parameters related to the method as well as various parameters of this media. The results of these experiments confirm that the depth sensitivity of the subtraction-based approach is better than classical approaches using continuous-wave or time-resolved methods. Furthermore, the results showed that the subtraction-based approach has a unique, selective sensitivity to a layer at a specific depth. In vivo application of the proposed method resulted in a greater magnitude of the hemodynamic changes during functional activation than with the standard approach.

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Daniel Milej, Androu Abdalmalak, Peter McLachlan, Mamadou Diop, et al.. "Subtraction-based approach for enhancing the depth sensitivity of time-resolved NIRS" Biomedical Optics Express (2016) p. 4514 - 4526
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