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Selected Works of Keith St. Lawrence
Article
Quantification of joint inflammation in rheumatoid arthritis by time-resolved diffuse optical spectroscopy and tracer kinetic modeling
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
  • Seva Ioussoufovitch, Lawson Health Research Institute
  • Laura B. Morrison, Western University
  • Ting Yim Lee, Lawson Health Research Institute
  • Keith St. Lawrence, Lawson Health Research Institute
  • Mamadou Diop, Lawson Health Research Institute
Document Type
Conference Proceeding
Publication Date
1-1-2015
URL with Digital Object Identifier
10.1117/12.2079811
Abstract

© 2015 SPIE. Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation, which can cause progressive joint damage and disability. Diffuse optical spectroscopy (DOS) and imaging have the potential to become potent monitoring tools for RA. We devised a method that combined time-resolved DOS and tracer kinetics modeling to rapidly and reliably quantify blood flow in the joint. Preliminary results obtained from two animals show that the technique can detect joint inflammation as early as 5 days after onset.

Citation Information
Seva Ioussoufovitch, Laura B. Morrison, Ting Yim Lee, Keith St. Lawrence, et al.. "Quantification of joint inflammation in rheumatoid arthritis by time-resolved diffuse optical spectroscopy and tracer kinetic modeling" Progress in Biomedical Optics and Imaging - Proceedings of SPIE (2015)
Available at: http://works.bepress.com/keith-stlawrence/40/