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Article
Quantification of joint blood flow by dynamic contrast-enhanced near-infrared spectroscopy: Application to monitoring disease activity in a rat model of rheumatoid arthritis
Journal of Biomedical Optics
  • Seva Ioussoufovitch, Western University
  • Laura B. Morrison, Lawson Health Research Institute
  • Lise Desjardins, Lawson Health Research Institute
  • Jennifer A. Hadway, Lawson Health Research Institute
  • Keith St Lawrence, Lawson Health Research Institute
  • Ting Yim Lee, Lawson Health Research Institute
  • Frank Beier, Western University
  • Mamadou Diop, Western University
Document Type
Article
Publication Date
1-1-2020
URL with Digital Object Identifier
10.1117/1.JBO.25.1.015003
Disciplines
Abstract

© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Significance: Current guidelines for rheumatoid arthritis (RA) management recommend early treatment with disease modifying antirheumatic drugs (DMARDs). However, DMARD treatment fails in 30% of patients and current monitoring methods can only detect failure after 3 to 6 months of therapy. Aim: We investigated whether joint blood flow (BF), quantified using dynamic contrast-enhanced time-resolved near-infrared spectroscopy, can monitor disease activity and treatment response in a rat model of RA. Approach: Ankle joint BF was measured every 5 days in eight rats with adjuvant-induced arthritis (AIA) and four healthy controls. Arthritis was allowed to progress for 20 days before rats with AIA were treated with a DMARD once every 5 days until day 40. Results: Time and group had separate significant main effects on joint BF; however, there was no significant interaction between time and group despite a notable difference in average joint BF on day 5. Comparison of individual blood flow measures between rats with AIA and control group animals did not reveal a clear response to treatment. Conclusions: Joint BF time courses could not distinguish between rats with AIA and study controls. Heterogeneous disease response and low temporal frequency of BF measurements may have been important study limitations.

Citation Information
Seva Ioussoufovitch, Laura B. Morrison, Lise Desjardins, Jennifer A. Hadway, et al.. "Quantification of joint blood flow by dynamic contrast-enhanced near-infrared spectroscopy: Application to monitoring disease activity in a rat model of rheumatoid arthritis" Journal of Biomedical Optics (2020)
Available at: http://works.bepress.com/keith-stlawrence/37/