Skip to main content
Article
Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: Protocol for DIET-HD, a prospective multinational cohort study
B M J Group
  • Suetonia C Palmer, Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand
  • Marinella Ruospo, Diaverum Medical Scientific Office, Lund, Sweden
  • Katrina Campbell, Bond University
  • Vanessa G Larsen, Imperial College of Science, Technology, and Medicine, London, UK
  • Valeria Saglimbene, Diaverum Medical Scientific Office, Lund, Sweden
  • Patrizia Natale, Diaverum Medical Scientific Office, Lund, Sweden
  • Letizia Gargano, Diaverum Medical Scientific Office, Lund, Sweden
  • Jonathan C Craig, University of Sydney
  • David W Johnson, Princess Alexandra Hospital
  • Marcello Tonelli, University of Calgary, Canada
  • John Knight, The George Institute for Global Health, Sydney
  • Anna Bednarek-Skublewska, Medical University of Lublin, Lublin, Poland
  • Eduardo Celia, Diaverum Medical Scientific Office, Lund, Sweden
  • Domingo del Castillo, Diaverum Medical Scientific Office, Lund, Sweden
  • Jan Dulawa, Medical University of Silesia, Katowice, Poland
  • Tevfik Ecder, Diaverum Medical Scientific Office, Lund, Sweden
  • Elisabeth Fabricius, Diaverum Medical Scientific Office, Lund, Sweden
  • Joao M Frazao, Diaverum Medical Scientific Office, Lund, Sweden
  • Ruben Gelfman, Diaverum Medical Scientific Office, Lund, Sweden
  • Susanne H Hoischen, Diaverum Medical Scientific Office, Lund, Sweden
  • Steffan Schon, Diaverum Medical Scientific Office, Lund, Sweden
  • Paul Stroumza, Diaverum Medical Scientific Office, Lund, Sweden
  • Delia Timofte, Diaverum Medical Scientific Office, Lund, Sweden
  • Marietta Torok, Diaverum Medical Scientific Office, Lund, Sweden
  • Jorgen Hegbrant, Diaverum Medical Scientific Office, Lund, Sweden
  • Charlotta Wollheim, Diaverum Medical Scientific Office, Lund, Sweden
  • Luc Frantzen, Diaverum Medical Scientific Office, Lund, Sweden
  • G F M Strippoli, Diaverum Medical Scientific Office, Lund, Sweden
Date of this Version
1-1-2015
Document Type
Journal Article
Publication Details

Published version

Palmer, S., C. Ruospo, M., Campbell, K. L., Garcia Larsen, V., Saglimbene, V., Natale, P., Gargano, L., Craig, J. C., Johnson, D. W.,Tonelli, M., Knight, J., Bednarek-Skublewska, A., Celia, E., del Castillo, D., Dulawa, J., Ecder, T., Fabricius, E., Frazão, J. M., Gelfman, R., Hoischen, S. H., Schön, S., Stroumza, P.,Timofte, D., Török, M., Hegbrant, J., Wollheim, C., Frantzen,L., & Strippoli, G. F. M. (2015). Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: Protocol for DIET-HD, a prospective multinational cohort study. BMJ Open, 5(3), 1-8.

Access the journal

2015 HERDC submission

© Copyright, The Authors, 2015

Distribution License
Creative Commons Attribution-Noncommercial 4.0
Abstract
Introduction Adults with end-stage kidney disease (ESKD) treated with haemodialysis experience mortality of between 15% and 20% each year. Effective interventions that improve health outcomes for long-term dialysis patients remain unproven. Novel and testable determinants of health in dialysis are needed. Nutrition and dietary patterns are potential factors influencing health in other health settings that warrant exploration in multinational studies in men and women treated with dialysis. We report the protocol of the “DIETary intake, death and hospitalisation in adults with end-stage kidney disease treated with HaemoDialysis (DIET-HD) study,” a multinational prospective cohort study. DIET-HD will describe associations of nutrition and dietary patterns with major health outcomes for adults treated with dialysis in several countries. Methods and analysis DIET-HD will recruit approximately 10 000 adults who have ESKD treated by clinics administered by a single dialysis provider in Argentina, France, Germany, Hungary, Italy, Poland, Portugal, Romania, Spain, Sweden and Turkey. Recruitment will take place between March 2014 and June 2015. The study has currently recruited 8000 participants who have completed baseline data. Nutritional intake and dietary patterns will be measured using the Global Allergy and Asthma European Network (GA2LEN) food frequency questionnaire. The primary dietary exposures will be n-3 and n-6 polyunsaturated fatty acid consumption. The primary outcome will be cardiovascular mortality and secondary outcomes will be all-cause mortality, infection-related mortality and hospitalisation. Ethics and dissemination The study is approved by the relevant Ethics Committees in participating countries. All participants will provide written informed consent and be free to withdraw their data at any time. The findings of the study will be disseminated through peer-reviewed journals, conference presentations and to participants via regular newsletters. We expect that the DIET-HD study will inform large pragmatic trials of nutrition or dietary interventions in the setting of advanced kidney disease.
Citation Information
Suetonia C Palmer, Marinella Ruospo, Katrina Campbell, Vanessa G Larsen, et al.. "Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: Protocol for DIET-HD, a prospective multinational cohort study" B M J Group Vol. 5 Iss. 3 (2015) p. 1 - 8 ISSN: 2044-6055
Available at: http://works.bepress.com/katrina-campbell/14/