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Article
Defects in Apoptosis Increase Memory CD8+ T cells Following Infection of Bim^-/- Fas^lpr/lpr Mice
Cellular Immunology
  • Ashley E. Weant, Wake Forest University School of Medicine
  • Ryan D. Michalek, Metabolon Corporation
  • Katie E. Crump, Wake Forest University School of Medicine
  • Andrew P. Konopitski, Wake Forest University School of Medicine
  • Jason M. Grayson, Wake Forest University School of Medicine
Document Type
Article
Publication Date
7-1-2011
Keywords
  • Apoptosis,
  • Viral infection,
  • Cytolytic T cells
Disciplines
Abstract
During many infections, large numbers of effector CD8+ T cells are generated. After pathogen clearance, the majority of these cells undergo apoptosis, while the survivors differentiate into memory CD8+ T cells. Although loss of both Bim and Fas function dramatically increased antigen-specific CD8+ T cells in the lymph nodes following acute lymphocytic choriomeningitis virus (LCMV) infection, it was unclear whether they were pardoned effector or true memory CD8+ T cells. In this study, we demonstrate they are bona fide memory T cells as characterized by surface marker expression, cytokine production, homeostatic proliferation, and ability to clear a secondary challenge of pathogen. Loss of both Bim and Fas also increased the number of virus-specific CD4+ T cells found in the lymph nodes compared to the parental genotypes or wildtype mice. These studies illustrate that decreasing apoptosis increases the number of memory T cells and therefore could increase the efficacy of vaccines.
DOI
10.1016/j.cellimm.2011.07.003
Citation Information
Ashley E. Weant, Ryan D. Michalek, Katie E. Crump, Andrew P. Konopitski, et al.. "Defects in Apoptosis Increase Memory CD8+ T cells Following Infection of Bim^-/- Fas^lpr/lpr Mice" Cellular Immunology Vol. 271 Iss. 2 (2011) p. 256 - 266 ISSN: 0008-8749
Available at: http://works.bepress.com/katie-crump/9/