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About Kathryn E. Splan

Kathryn Splan is an inorganic and biochemist with a background in porphyrin chemistry and medicinal biochemistry. She arrived at Macalester in the Fall of 2007 and teaches in both the biochemistry and introductory chemistry sequences. Her current research focuses on Inhibitor of Apoptosis Proteins (IAPs), which play a key role in the control of programmed cell death. Specifically, her current work focuses on the development and characterization multivalent peptide inhibitors that target IAPs and explores the metal binding properties of IAPs from a bioinorganic and biophysical perspective. Prof. Splan is excited to pursue her varied research interests alongside Macalester students with interests at the interface of Chemistry and Biology.
Splan's dissertation, Development and Characterization of Porphyrin Chromophores for Solar Energy Conversion, focuses on the synthesis and fundamental photophysical and photoelectrochemical properties of porphyrin compounds in the context of solar energy conversion.
Her postdoctoral work at Duke University and the University of Minnesota was broadly focused on protein chemistry. Her current interests include the characterization of peptide-protein interactions and the metal-binding properties of apoptotic proteins involved in cell-death pathways.
EDUCATION: B.S., University of Wisconsin, Eau Claire
Ph.D., Northwestern University
Splan has been teaching at Macalester since 2007.


Present Associate Professor, Chemistry, Macalester College



  • General Chemistry II
  • Biochemistry I
  • Biochemistry I lab

Contact Information

Macalester College
Olin Rice 311
1600 Grand Avenue
St. Paul, MN 55105