Nursing students often find pathophysiology challenging and articles examining effective teaching-learning strategies to address these challenges are limited. The objective of this study was to develop, implement, and evaluate the effectiveness of a new model for teaching pathophysiology in nursing education. A quasi-experimental study guided by Analyze, Design, Develop, Implement, and Evaluate (ADDIE) Model and Bloom's Taxonomy was used to develop and implement the Combine, Question, Apply (CQA) Model for three academic years to 190 nursing students enrolled in pathophysiology courses. Surveys, descriptive frequencies, independent t-tests, and qualitative measures were completed. Course and small group activities were highly rated. Student grades statistically had a gradual improvement following the CQA Model implementation (p = <.001). Following the CQA Model implementation, student performance improved. Students valued the online recorded videos and small group activities. This CQA Model may be applicable in other nursing and related professional courses.