We found that location-level factors were most important in describing reptile establishment success, followed by event- and species-level factors, respectively. This pattern matches closely with what others have found in a variety of vertebrate taxa. However, the importance of species traits may be underestimated considering the insufficient knowledge of reptile life history within introduced ranges. Importantly, individual variables from all three hypotheses contributed to global reptile establishment. Managers should be especially cognizant of small herbivorous and fecund reptiles that are frequently introduced into areas with a strong climate match to their native range. Further, parthenogenesis greatly facilitated establishment, indicating that obligate parthenogenetic species may become ubiquitous through modern globalized trade.