Objective - To compare the effectiveness of preoperative PO and SC administration of buprenorphine and meloxicam for prevention of postoperative pain-associated behaviors in cats undergoing ovariohysterectomy. Design - Randomized controlled study. Animals - 51 female cats (4 to 60 months old; weight range, 1.41 to 4.73 kg [3.1 to 10.4 lb]). Procedure - Cats received 1 of 5 treatments at the time of anesthetic induction: buprenorphine PO (0.01 mg/kg [0.0045 mg/lb]; n=10), buprenorphine SC (0.01 mg/kg; 10), meloxicam SC (0.3 mg/kg [0.14 mg/lb]; 10), meloxicam PO (0.3 mg/kg; 10), or 0.3 mL of sterile saline (0.9% NaCl) solution SC (control group; 11). Sedation scores and visual analogue scale and interactive visual analogue scale (IVAS) pain-associated behaviour scores were assigned to each cat 2 hours before and at intervals until 20 hours after surgery. Results - Cats receiving meloxicam PO or SC had significantly lower IVAS scores (2.91 and 2.02, respectively), compared with IVAS scores for cats receiving buprenorphine PO (7.55). Pain-associated behaviour scores for cats administered buprenorphine or meloxicam PO or SC preoperatively did not differ significantly from control group scores. Rescue analgesia was not required by any of the cats receiving meloxicam, whereas 3 of 10 cats receiving buprenorphine PO, 2 of 10 cats receiving buprenorphine SC, and 1 of 11 cats receiving the control treatment required rescue analgesia. Conclusions and Clinical Relevance - On the basis of pain-associated behaviour scores, cats receiving meloxicam PO or SC before ovariohysterectomy appeared to have less pain after surgery than those receiving buprenorphine PO preoperatively.
- anaesthesia anaesthetics analgesics oral administration pain potency subcutaneous injection surgery cats anesthesia anesthetics buprenorphines meloxicam ovariohysterectomy pain killers Felis Felidae Fissipeda carnivores mammals vertebrates Chordata animals small mammals eukaryotes
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