Objective—To integrate home demands with the Demand-Control-Support model to test if home demands interact with job strain to increase depressive symptoms. Methods—Data were from 431 employees in four extended care facilities. Presence of a child under age 18 in the household signified home demands. The outcome was depressive symptoms based on a shortened version of the Center for Epidemiologic Studies Depression Scale. Results—The association between job strain and depressive symptoms was moderated by social support (SS) and presence of a child in the household (child). There was no association among participants with high SS and no child, but a positive one among participants with low SS and a child. Conclusions—Job strain may be a particularly important determinant of depressive symptoms among employees with family demands. Models of job strain should expand to incorporate family demands.