Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women (Atherosclerosis)Atherosclerosis (2011)
Background: Although fatty acid composition in serum and desaturase activity, which alters serum fatty acid composition, has been associated with C-reactive protein (CRP) concentration in Western populations, no study has been carried out in non-Western populations. We examined the association of serum fatty acids and estimated desaturase activity with CRP concentrations in Japanese men and women.
Methods: Subjects were 489 Japanese municipal employees aged 21–67 yearswhoparticipated in a survey at the time of a periodic health check-up. Serum high-sensitivity CRP concentrations were measured using the latex agglutination nephelometry method. Fatty acid composition was measured in serum cholesteryl esters and desaturase activities by fatty acid product-to-precursor ratios. Relationships were assessed using multiple regression.
Results: Serum CRP concentration was positively associated with palmitic acid (P for trend = 0.002) and inversely with alpha-linolenic acid (P for trend = 0.01) in men, and positively with dihomogamma-
linolenic acid (P for trend in men or women= 0.01) and inversely with delta-5-desaturase (20:4n-6/20:3n-6) (P for trend in men and women= 0.05 and 0.002, respectively) in men and women.
Conclusions: Low-grade inflammation may be associated with a serum fatty acid pattern of high palmitic acid or low alpha-linolenic acid in men, and of high dihomo-gamma-linolenic acid or low delta-5-
desaturase in both sexes.
- C-reactive protein,
- Desaturase activity,
- Elongase activity,
- Fatty acid composition
Publication DateFall November 19, 2011
Citation InformationKalpana Poudel-Tandukar, Masao Sato, Yuko Ejima, Akiko Nanri, et al.. "Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women (Atherosclerosis)" Atherosclerosis Vol. 220 Iss. 2 (2011) p. 520 - 524
Available at: http://works.bepress.com/kalpana-poudel-tandukar/15/