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Contribution to Book
MicroRNAs and their emerging roles in immunology
Science and Mathematics Faculty Publications
  • Kaleb M. Pauley, Cedarville University
  • E. K. Chan
Document Type
Article
Publication Date
11-19-2008
Abstract
MicroRNAs (miRNAs) are evolutionarily conserved small noncoding RNAs that post-transcriptionally regulate gene expression by targeting specific messenger RNAs (mRNAs) for degradation or translational repression. Recent evidence indicates that miRNA-mediated gene regulation is critical for normal cellular functions, and as much as one-third of human mRNAs may be miRNA targets. Emerging evidence suggests that miRNAs play a key role in the regulation of immunological functions including innate and adaptive immune responses, development and differentiation of immune cells, and the prevention of autoimmunity. Here, we review the mechanisms of miRNA maturation and function, the roles of several miRNAs in immunological functions, and the involvement of miRNAs in disease pathogenesis.
Keywords
  • GW body,
  • microRNA,
  • RNA interference
Comments

In NR Rose (Ed.), Annals of the New York Academy of Sciences: The Year in Immunology 2008.. Malden, MA: Blackwell Publishing.

Citation Information
Kaleb M. Pauley and E. K. Chan. "MicroRNAs and their emerging roles in immunology" (2008)
Available at: http://works.bepress.com/kaleb_pauley/28/