Skip to main content
Article
A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence
Department of Biological Sciences
  • Deepak Balasubramania, Department of Biological Sciences and Herbert Werhteim College of Medicine, Florida International University
  • Lisa Schneper, Herbert Werthiem College of Medicine, Florida International University
  • Hansi Kumari, Herbert Wertheim College of Medicine, Florida International University
  • Kalai Mathee, Herbert Wertheim College of Medicine, Florida International University
Date of this Version
11-11-2012
Document Type
Article
Disciplines
Abstract

Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing numerous acute and chronic infections. The critical traits contributing to the pathogenic potential of P. aeruginosa are the production of a myriad of virulence factors, formation of biofilms and antibiotic resistance. Expression of these traits is under stringent regulation, and it responds to largely unidentified environmental signals. This review is focused on providing a global picture of virulence gene regulation in P. aeruginosa. In addition to key regulatory pathways that control the transition from acute to chronic infection phenotypes, some regulators have been identified that modulate multiple virulence mechanisms. Despite of a propensity for chaotic behaviour, no chaotic motifs were readily observed in the P. aeruginosa virulence regulatory network. Having a ‘birds-eye’ view of the regulatory cascades provides the forum opportunities to pose questions, formulate hypotheses and evaluate theories in elucidating P. aeruginosa pathogenesis. Understanding the mechanisms involved in making P. aeruginosa a successful pathogen is essential in helping devise control strategies.

Comments

Originally published by Oxford University Press.

Creative Commons License
Creative Commons Attribution-Noncommercial 3.0
Citation Information
Deepak Balasubramania, Lisa Schneper, Hansi Kumari and Kalai Mathee. "A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence" (2012)
Available at: http://works.bepress.com/kalai_mathee/6/