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Comparative transcriptome analyses of Pseudomonas aeruginosa
HWCOM Faculty Publications
  • Deepak Balasubramanian, Florida International University, Department of Biological Sciences
  • Kalai Mathee, Florida International University, Department of Molecular Microbiology and Infectious Diseases, College of Medicine
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One of the hallmarks of bacterial survival is their ability to adapt rapidly to changing environmental conditions. Niche adaptation is a response to the signals received that are relayed, often to regulators that modulate gene expression. In the post-genomic era, DNA microarrays are used to study the dynamics of gene expression on a global scale. Numerous studies have used Pseudomonas aeruginosa--a Gram-negative environmental and opportunistic human pathogenic bacterium--as the model organism in whole-genome transcriptome analysis. This paper reviews the transcriptome studies that have led to immense advances in our understanding of the biology of this intractable human pathogen. Comparative analysis of 23 P. aeruginosa transcriptome studies has led to the identification of a unique set of genes that are signal specific and a core set that is differentially regulated. The 303 genes in the core set are involved in bacterial homeostasis, making them attractive therapeutic targets.


This article was originall published in Human Genomics

©2009 Henry Stewart Publications

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citation Information
Deepak Balasubramanian and Kalai Mathee. "Comparative transcriptome analyses of Pseudomonas aeruginosa" (2009)
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