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Materials for diabetes therapeutics
Advanced Healthcare Materials (2012)
  • Kaitlin M. Bratlie, Massachusetts Institute of Technology
  • Roger L. York, Massachusetts Institute of Technology
  • Michael A. Invernale, Massachusetts Institute of Technology
  • Robert Langer, Massachusetts Institute of Technology
  • Daniel G. Anderson, Massachusetts Institute of Technology
This review is focused on the materials and methods used to fabricate closedloop systems for type 1 diabetes therapy. Herein, we give a brief overview of current methods used for patient care and discuss two types of possible treatments and the materials used for these therapies-(i) artificial pancreases, comprised of insulin producing cells embedded in a polymeric biomaterial, and (ii) totally synthetic pancreases formulated by integrating continuous glucose monitors with controlled insulin release through degradable polymers and glucose-responsive polymer systems. Both the artificial and the completely synthetic pancreas have two major design requirements: the device must be both biocompatible and be permeable to small molecules and proteins, such as insulin. Several polymers and fabrication methods of artificial pancreases are discussed: microencapsulation, conformal coatings, and planar sheets. We also review the two components of a completely synthetic pancreas. Several types of glucose sensing systems (including materials used for electrochemical, optical, and chemical sensing platforms) are discussed, in addition to various polymer-based release systems (including ethylenevinyl acetate, polyanhydrides, and phenylboronic acid containing hydrogels).
  • amino acid,
  • benzeneboronic acid,
  • biomaterial,
  • glucose,
  • insulin,
  • artificial pancreas,
  • drug delivery system,
  • electrochemical analysis,
  • insulin dependent diabetes mellitus,
  • Hypoglycemic Agents
Publication Date
Publisher Statement
This is the peer reviewed version of the following article: Bratlie, K.M., York, R.L., Invernale, M.A., Langer, R., Anderson, D.G. Materials for diabetes therapeutics (2012) Advanced Healthcare Materials, 1 (3), pp. 267-284, which has been published in final form at 10.1002/adhm.201200037. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.
Citation Information
Kaitlin M. Bratlie, Roger L. York, Michael A. Invernale, Robert Langer, et al.. "Materials for diabetes therapeutics" Advanced Healthcare Materials Vol. 1 Iss. 3 (2012)
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