Microfabrication of homogenous, asymmetric cell-laden hydrogel capsulesBiomaterials (2009)
AbstractCell encapsulation has been broadly investigated as a technology to provide immunoprotection for transplanted endocrine cells. Here we develop a new fabrication method that allows for rapid, homogenous microencapsulation of insulin-secreting cells with varying microscale geometries and asymmetrically modified surfaces. Micromolding systems were developed using polypropylene mesh, and the material/surface properties associated with efficient encapsulation were identified. Cells encapsulated using these methods maintain desirable viability and preserve their ability to proliferate and secrete insulin in a glucose-responsive manner. This new cell encapsulation approach enables a practical route to an inexpensive and convenient process for the generation of cell-laden microcapsules without requiring any specialized equipment or microfabrication process.
- cell encapsulation,
- hydrogel microcapsules,
- polypropylene mesh
Citation InformationQiaobing Xu, Tram T. Dang, Kaitlin M. Bratlie, Ivy Chen, et al.. "Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules" Biomaterials Vol. 30 Iss. 36 (2009)
Available at: http://works.bepress.com/kaitlin_bratlie/12/