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Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules
Biomaterials (2009)
  • Qiaobing Xu, Massachusetts Institute of Technology
  • Tram T. Dang, Massachusetts Institute of Technology
  • Kaitlin M. Bratlie, Massachusetts Institute of Technology
  • Ivy Chen, Massachusetts Institute of Technology
  • Robert Langer, Massachusetts Institute of Technology
  • Daniel G. Anderson, Massachusetts Institute of Technology
Cell encapsulation has been broadly investigated as a technology to provide immunoprotection for transplanted endocrine cells. Here we develop a new fabrication method that allows for rapid, homogenous microencapsulation of insulin-secreting cells with varying microscale geometries and asymmetrically modified surfaces. Micromolding systems were developed using polypropylene mesh, and the material/surface properties associated with efficient encapsulation were identified. Cells encapsulated using these methods maintain desirable viability and preserve their ability to proliferate and secrete insulin in a glucose-responsive manner. This new cell encapsulation approach enables a practical route to an inexpensive and convenient process for the generation of cell-laden microcapsules without requiring any specialized equipment or microfabrication process.
  • Alginate,
  • cell encapsulation,
  • diabetes,
  • hydrogel microcapsules,
  • microfabrication,
  • polypropylene mesh
Publication Date
Publisher Statement
This is the author’s version of a work that was accepted for publication in Biomaterials. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biomaterials, 30 (36), 2009, DOI: 10.1016/j.biomaterials.2009.09.012.
Citation Information
Qiaobing Xu, Tram T. Dang, Kaitlin M. Bratlie, Ivy Chen, et al.. "Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules" Biomaterials Vol. 30 Iss. 36 (2009)
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