Article
Anti-Hepatitis B Virus Activity of ORI-9020, a Novel Phosphorothioate Dinucleotide, in a Transgenic Mouse Model
Antimicrobial Agents and Chemotherapy
(2004)
Abstract
ORI-9020, a novel dinucleotide, evaluated in transgenic mice expressing hepatitis B virus (HBV), significantly reduced liver HBV DNA (P <= 0.001). Levels of HBeAg and HBsAg in serum and of HBcAg in liver were not affected by treatment. A minimal effective dosage was determined to be between 1.6 and 0.5 mg/kg of body weight/day, which was similar to that observed for adefovir dipivoxil.
Keywords
- anti hepatitis b,
- virus activity,
- ORI-9020,
- phosphorothioate,
- dinucleotide,
- transgenic,
- mouse
Disciplines
Publication Date
January 1, 2004
Publisher Statement
Originally published by the American Society for Microbiology. Publisher's PDF and HTML fulltext available through remote link.
Citation Information
Iyer, R.P., A. Roland, Y. Jin, S. Mounir, B. Korba, J.G. Julander, and J.D. Morrey 2004. Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model Antimicrobial Agents and Chemotherapy 48(6): 2318-2320.