Article
A multi-institutional outcome analysis of patients undergoing left ventricular assist device implantation stratified by sex and race
J Heart Lung Transplant
(2017)
Abstract
Background: Earlier studies have demonstrated disparities in patients undergoing left ventricular assist device (LVAD) implantation when stratified according to sex and race. Because very few data exist from large investigations, we reviewed data from the registry of the Mechanical Circulatory Support Research Network.
Methods: Between May 2004 and September 2014, 734 patients underwent primary LVAD implantation at our institutions. Median age at implant was 57 (range 18 to 82) years and there were 577 males (80%). Race included Caucasian (C) in 586 patients (82%), African-American (AA) in 112 (16%), and other (O) in 21 (3%). Between sexes, significant pre-operative differences most commonly included median age at implant (males 60 years, females 57 years), ischemic etiology (53% vs 35%) and mean INTERMACS profile (2.9 vs 2.5). Between races, significant pre-operative differences most commonly included median age at implant (C = 61 vs AA = 51 vs O = 51), New York Heart Association functional class (85% vs 100% vs 92%) and ischemic etiology (55% vs 24% vs 40%).
Results: There were no significant differences in survival at 1, 3 or 5 years by sex or race. Similarly, there were no differences in time-related freedom from stroke, drive-line infection, gastrointestinal bleeding or pump thrombus by sex or race. After controlling for differences, neither sex nor race was associated with survival (p = 0.09 and p = 0.18, respectively), stroke (p = 0.28 and p = 0.21), drive-line infection (p = 0.9 and p = 0.92), gastrointestinal bleed (p = 0.48 and p = 0.45) or pump thrombus (p = 0.99 and p = 0.8).
Conclusions: In this large, multi-institutional analysis, although some pre-operative clinical characteristics varied, they did not translate into any significant differences in late survival or complications while on LVAD support.
Keywords
- disparities,
- mechanical circulatory assistance,
- race,
- ventricular assist device
Disciplines
Publication Date
January, 2017
DOI
10.1016/j.healun.2016.08.027
Publisher Statement
Copyright © 2016 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
Citation Information
Justin R. Van Meeteren, Simon Maltais, Shannon Dunlay, Nicholas A Haglund, et al.. "A multi-institutional outcome analysis of patients undergoing left ventricular assist device implantation stratified by sex and race" J Heart Lung Transplant Vol. 36 Iss. 1 (2017) p. 64 - 70 Available at: http://works.bepress.com/justin-vanmeeteren/1/
Creative Commons license
![Creative Commons License](https://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons CC_BY International License.