Far-end crosstalk (FEXT) noise is one of the major issues that limits signal integrity performance for high-speed digital products. It is important to estimate the crosstalk noise accurately to avoid noise margin failure or overdesigned transmission lines. Traditionally, analytical formulas for crosstalk noise are based on lossless and perfect impedance match assumptions, which provide limited guidance for a practical high-speed transmission line design. A phenomenon is observed that a lossy conductor increases the FEXT on coupled striplines. To provide a reasonable explanation, analytical and numerical investigations were performed using a modal analysis based approach. A new FEXT component due to the lossy conductor is proposed. Such FEXT component is important to a high-speed stripline design because it is a major contributor when all terminals are matched. To estimate the impact of loss on FEXT, a practical and fast estimation approach is proposed.