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Article
Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice
Microbiology and immunology
  • Jumpei Uchiyama, Bond University
  • Yoshihiro Maeda
  • Iyo Takemura
  • Russ Chess-Williams, Bond University
  • Hiroshi Wakiguchi
  • Shigenobu Matsuzaki
Date of this Version
1-1-2009
Document Type
Journal Article
Publication Details
Interim status: Citation only.

Uchiyama, J., Maeda, Y., Takemura, I., Chess-Williams, R., Wakiguchi, H., & Matsuzaki, S. (2009). Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice. Microbiology and immunology, 53(5), 301-304.

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2009 HERDC submission. FoR code: 0605; 1107; 1108

© Copyright 2009 The Societies and Blackwell Publishing Asia Pty Ltd
Abstract
Due to multiple-drug resistant bacteria, phage therapy is being revisited. Although most animal experiments focus on therapeutic efficacy, the blood clearance kinetics of phages have not been well described. For further development of an efficient therapeutic strategy, information on phage blood kinetics is important. In this study, time-course concentration changes in peripheral blood of healthy and neutropenic mice were measured using four therapeutic phages (φMR11, KPP10, φEF24C, and KEP10). The results showed a two- to three-day rapid phage clearance, which fits a two-compartment model.
Citation Information
Jumpei Uchiyama, Yoshihiro Maeda, Iyo Takemura, Russ Chess-Williams, et al.. "Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice" Microbiology and immunology Vol. 53 Iss. 5 (2009) p. 301 - 304
Available at: http://works.bepress.com/jumpei_uchiyama/1/