The historical literature on Cameroon’s Anglophone Crisis traces its origin to the failure to implement the Foumban Constitutional Agreement. The current study adds a new perspective: Based on extensive field work in Cameroon and a variety of primary and secondary sources, this paper argues that Cameroon’s Anglophone Crisis, which began in October 2016, degenerated into violence because of a catalogue of miscalculations made by President Paul Biya’s regime. It also argues that the crisis has had a devastating impact on the way of life in the Anglophone region. This paper concludes with recommendations on what needs to be done to turn the tide in the Anglophone region. This study not only fills an important gap in the literature on the Anglophone Crisis and on the struggle for change in the country; it also contributes to postcolonial Cameroonian and African historiography overall.