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The Search for Anticarcinogenic Organoselenium Compounds from Natural Sources
Phosphorous, Sulfur and Silicon (1998)
  • Julian Tyson
  • Eric Block
  • Susan M. Bird
  • Peter C. Uden
  • Xing Zhang
  • Eric Denoyer
Conswnption of Se-enriched plants or yeast-based
nutritional supplements is reported to reduce the risk of cancer. Separation
and identification of natural organoselenium compounds in these plants is
essential to understand the basis for their biological activity. Earlier work
suggests that plants convert inorganic selenium in the soil or growth
medium into organoselenium compounds, such as selenoamino acids,
following a route similar to the sulfur assimilatory pathway. To separate
and detect selenoamino acids in plant extracts, we employ ion pair LC with
an inductively coupled plasma mass spectrometer (ICP-MS) detector and
capillary GC with an atomic emission detector (AED), for underivatized
and derivatized compounds, respectively. Volatile selenium compounds,
such as those found in human garlic breath, have been analyzed using GCAED.
Results involving Se-enriched garlic and yeast-based nutritional
supplements are presented.
  • Selenoamino acids,
  • ICP-MS,
  • GC-AED,
  • garlic (Allium sativum),
  • yeast
Publication Date
Citation Information
Julian Tyson, Eric Block, Susan M. Bird, Peter C. Uden, et al.. "The Search for Anticarcinogenic Organoselenium Compounds from Natural Sources" Phosphorous, Sulfur and Silicon Vol. 136, 137 &138 (1998) p. 1 - 10
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