Skip to main content
Article
The Design of Flow Injection Manifolds to Give the Best Detection Limits for Methods Involving On-Line Chemical Derivatisation. Part 1. Theoretical Basis for High Sensitivity
Quimica Analitica (1989)
  • Julian Tyson
Abstract
The criteria to be considered when designing a flow-injection manifold
for the highest sensitivity for a method based on measurement
of the peak height corresponding to a derivative formed on-line between
the injectate and a reagent. These criteria include the ratio
of reagent concentration to determinand concentration at the peak
maximum, the concentration of the top standard and the reagent
composition. These three parameters can be combined to give a
single parameter referred to as the a-value being the ratio of the
determinand to reagent dispersion coefficients at the peak maximum
for the top standard. It is shown, on the basis of the single, wellstirred
tank model that the required dispersion coefficient is (1 +
a) for both a single-line and a double-line manifold. It is further
shown that the throughput for the former manifold would be
higher than that of the latter.
Keywords
  • Flow injection analysis,
  • manifold design,
  • dispersion coefficient,
  • sensitivity,
  • throughput,
  • well-stirred tank model
Publication Date
1989
Citation Information
Julian Tyson. "The Design of Flow Injection Manifolds to Give the Best Detection Limits for Methods Involving On-Line Chemical Derivatisation. Part 1. Theoretical Basis for High Sensitivity" Quimica Analitica Vol. 8 (1989) p. 171
Available at: http://works.bepress.com/julian_tyson/167/