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Presentation
Advancing Stage of Female Reproductive Life Associated with Bipolar Illness Exacerbation
UMass Center for Clinical and Translational Science Research Retreat
  • Wendy K. Marsh, University of Massachusetts Medical School
  • Terence Ketter, Stanford University School of Medicine
  • Sybil L. Crawford, University of Massachusetts Medical School
  • Julia V. Johnson, University of Massachusetts Medical School
  • Anthony J. Rothschild, University of Massachusetts Medical School
Start Date
20-5-2011 5:00 PM
End Date
20-5-2011 7:00 PM
Description

Introduction: Perimenopause confers an increased risk of depression in the general population, yet bipolar disorder mood course remains unknown.

Methods: Clinic visits in 519 premenopausal, 116 perimenopausal including 13 women transitioning from peri- to postmenopause, and 133 postmenopausal women with bipolar disorder who received naturalistic treatment in the multisite STEP-Bipolar Disorder study over 19.8 +/- 15.5 months were analyzed for mood state.

Results: Advancing female reproductive stage was associated with significant decline in mood elevation; significant decline in euthymia; no significant difference in major depression; and symptomatic significant increase.

Conclusions: Advancing stage of female reproductive life was associated with bipolar illness exacerbation. Women transitioning from peri- to postmenopause had significantly greater depression than other female reproductive groups.

Creative Commons License
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Citation Information
Wendy K. Marsh, Terence Ketter, Sybil L. Crawford, Julia V. Johnson, et al.. "Advancing Stage of Female Reproductive Life Associated with Bipolar Illness Exacerbation" (2011)
Available at: http://works.bepress.com/julia_johnson/5/