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Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs
Veterinary Therapeutics (2002)
  • Darryl L. Millis, University of Tennessee - Knoxville
  • Joseph P. Weigel, University of Tennessee, Knoxville
  • Tamberlyn Moyers, University of Tennessee - Knoxville
  • Francis C. Buonomo
Abstract

Twenty-four healthy, mixed-breed hound-type dogs were evenly and randomly assigned to a placebo control group, one of four dosages of deracoxib (0.3, 1, 3, or 10 mg/kg), or carprofen (2.2 mg/kg). Oral dosing of placebo, carprofen, or deracoxib was done 30 minutes before intraarticular injection of urate crystal suspension for induction of synovitis. Ground reaction forces, subjective clinical lameness scores, pain, joint effusion, and quantitative pain threshold responses were measured in a blinded fashion before induction of synovitis and 2, 4, 6, 8, 12, and 24 hours after injection. The medium and high dosages of deracoxib were effective in preventing lameness and pain associated with synovitis. Carprofen was also somewhat effective in attenuating the severity of urate-induced synovitis but to a lesser degree than the medium dose of deracoxib. Preemptive deracoxib treatment at dosages as low as 1 mg/kg reduced lameness and pain of synovitis associated with intraarticular administration of urate crystals.

Publication Date
2002
Citation Information
Darryl L. Millis, Joseph P. Weigel, Tamberlyn Moyers and Francis C. Buonomo. "Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs" Veterinary Therapeutics Vol. 3 Iss. 4 (2002)
Available at: http://works.bepress.com/joseph_weigel/8/