The article extends the scholarship, observations, and recommendations provided in Joseph Gone’s article, “Psychotherapy and Traditional Healing for American Indians: Prospects for Therapeutic Integration” (2010 [this issue]). The overarching thesis is that for many Indian and Native clients, interpersonal and interethnic problems can emerge when a counselor’s lack of culturally resonant experience and knowledge, deeply held stereotypes, and preconceived notions interfere with the counseling relationship and impede counseling effectiveness. A brief synthesis of the counseling literature themes suggests that there is ample evidence that by using particular culturally resonant techniques, counselors can promote client trust, rapport, and cultural empathy and improve the counselor—client relationship, both in general and with American Indian and Alaska Native clients specifically. Topics consistent with Joseph Gone’s main thesis also are explored that relate to spiritual healing and other counseling considerations involving relational collaborations with Indian and Native communities. Information provided in this article is focused on helping to stimulate effective cross-cultural contacts between mental health counselors and Native American Indians.