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Article
Bioavailability and biochemical effects of diclofenac sodium 0.1% ophthalmic solution in the domestic chicken (Gallus gallus domesticus)
Veterinary Ophthalmology
  • Angela N. Griggs, Iowa State University
  • Taylor J. Yaw, Iowa State University
  • Joseph S. Haynes, Iowa State University
  • Gil Ben-Shlomo, Iowa State University
  • Kyle L. Tofflemire, Iowa State University
  • Rachel A. Allbaugh, Iowa State University
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
3-1-2017
DOI
10.1111/vop.12387
Abstract
Objective To determine if topical ophthalmic diclofenac sodium 0.1% solution alters renal parameters in the domestic chicken, and to determine if the drug is detectable in plasma after topical ophthalmic administration. Animals Thirty healthy domestic chickens Procedures Over seven days, 6 birds were treated unilaterally with 1 drop of artificial tear solution (group 1), 12 birds were treated unilaterally (group 2) and 12 bilaterally (group 3) with diclofenac sodium 0.1% ophthalmic solution. Treatments were provided for 7 days, every 12 hours in all groups. Pre- and post-treatment plasma samples from all birds were evaluated for changes in albumin, total protein, and uric acid. Post-treatment samples of all birds were also analyzed by HPLC-MS for detection of diclofenac sodium. Results Changes in pre- and post-treatment plasma albumin were significant (P < 0.05) in groups 2 and 3, but not for group 1. Pre- and post-treatment changes in total protein and uric acid pre- and post-treatment were not significant for any group. Diclofenac sodium was not detectable (limit of detection = 0.10 ng/mL) in plasma samples from birds in group 1. Concentration of drug in group 3 was statistically greater than group 2 (P = 0.0008). Conclusions and Clinical Relevance Topical ophthalmic diclofenac sodium 0.1% administered every 12 hours in one or both eyes for 7 days is detectable in systemic circulation in the domestic chicken at 15 minutes post-administration, but did not cause overt changes in parameters used to monitor renal physiology.
Comments

This is the peer reviewed version of the following article: Griggs, A. N., Yaw, T. J., Haynes, J. S., Ben-Shlomo, G., Tofflemire, K. L. and Allbaugh, R. A. (2017), Bioavailability and biochemical effects of diclofenac sodium 0.1% ophthalmic solution in the domestic chicken (Gallus gallus domesticus). Vet Ophthalmol, 20: 171–176, which has been published in final form at DOI: 10.1111/vop.12387. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

Copyright Owner
American College of Veterinary Ophthalmologists
Language
en
File Format
application/pdf
Citation Information
Angela N. Griggs, Taylor J. Yaw, Joseph S. Haynes, Gil Ben-Shlomo, et al.. "Bioavailability and biochemical effects of diclofenac sodium 0.1% ophthalmic solution in the domestic chicken (Gallus gallus domesticus)" Veterinary Ophthalmology Vol. 20 Iss. 2 (2017) p. 171 - 176
Available at: http://works.bepress.com/joseph-haynes/3/