The population’s increased intake of sugar-sweetened beverages is suggested to be a major contributor to the increased prevalence of obesity. Beverages are sweetened with a variety of different sugars. The objective of this study was to determine if the type of sugar consumed plays a role in lipogenesis, and the health effects. In this study, young female Sprague-Dawley rats were assigned to one of four treatments: deionized distilled water (ddH2O, control), ddH2O with sucrose, fructose, or high fructose corn syrup (HFCS-55). Samples were taken from the liver, and gonadal and retroperitoneal fat pads. Liver tissue was chosen because lipogenesis occurs in the liver. Our preliminary results showed that the final body weight was significantly greater (P<0.05) for the HFCS-55 group compared to the control and glucose groups. The liver weight was also significantly greater (P<0.05) for the HFCS-55 group compared to the control group. These values suggest that HFCS-55 is promoting lipogenesis. Research support provided by NRI grant #1004489R USDA-NIFA.